China Gbona Tita CAS 7361-61-7 Xylazine cannabinoids funfun lulú

Apejuwe

Xylazine jẹ agonist ti awọn olugba α2-adrenergic (Ki = 194 nM).O jẹ afọwọṣe ti clonidine, agonist olugba olugba α2-adrenergic ti a lo lati dinku titẹ ẹjẹ.Xylazine ti wa ni lilo fun sedation, akuniloorun, ati analgesia ni ti kii-eda eniyan osin.Ọja yii tun wa bi boṣewa itọkasi itupalẹ.
Olupilẹṣẹ Xylazine, Bayer

Nlo

Antinociceptive; Alpha-2 adrenergic agonist
Nlo

Xylazine jẹ kilasi α2 ti agonist olugba olugba adrenergic.Xylazine jẹ analoque clonidine kan ti o ṣiṣẹ lori presynaptic ati awọn olugba postsynaptic bi 2-adrenergic agonist.
Ilana iṣelọpọ

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), ti a pese sile lati 2,6-dimethylaniline pẹlu thiophosgene, ni a fi kun dropwise nigba 15 min si idaduro daradara ti 15.0 g (0.2 mole) ti 3-aminopropanol-1 in 100 milimita ti ether.Awọn ether bẹrẹ lati sise.Gbigbọn labẹ reflux ti tẹsiwaju fun awọn iṣẹju 30, ati pe ether ti distilled ni pipa.A tọju iyoku pẹlu 100 milimita ti ogidi hydrochloric acid ati sise labẹ reflux fun ọgbọn išẹju 30.Lẹhin itutu agbaiye, o ti fomi po pẹlu omi, ti a yọ kuro lati awọn aimọ, ati pe ipilẹ naa ti ṣaju nipasẹ afikun ti ojutu iṣuu soda hydroxide.Nigbati a ba tun ṣe atunṣe lati benzene-ligroin, abajade ti 2- (2,6- dimethyl-phenylamino) -4H-5,6-dihydro-1,3-thiazine, aaye yo 140-142 ° C (so 90% ti imọ-imọran ).
Isẹ-iwosan

Analgesic, Anesitetiki

Gbogbogbo Apejuwe

Xylazine jẹ tiotuka ninu kẹmika (50 mg/ml), ti nso ojutu ti ko ni awọ.O tun jẹ tiotuka ni dilute HCl acid ati ni chloroform.Xylazine jẹ adaṣe ti ko ṣee ṣe ninu omi ati ni awọn ojutu alkali.
Biochem/physiol Awọn iṣẹ

Xylazine nigba lilo pẹlu ketamine ni a gba pe o jẹ anesitetiki ti o lagbara ati ailewu ninu ẹranko adanwo.O jẹ mimọ lati gbe itusilẹ ẹdọ ẹdọ soke ti glukosi, eyiti o buru si hyperglycemia.
Mechanism ti igbese

Xylazine ti wa ni tita bi iyọ hydrochloride rẹ bi Rompun (100 mg/mL) ati Anased (20 mg/mL) awọn ojutu injectable fun iṣakoso iṣan si awọn ẹṣin ati awọn aja, lẹsẹsẹ.Awọn iṣe ti xylazine le jẹ iyipada nipasẹ iṣakoso ti yohimbine, alkaloid indolalkylamine kan, ti o dina awọn α2-adrenoreceptors wọnyẹn ti o ni itara nipasẹ xylazine.
Profaili Aabo

Majele nipasẹ jijẹ, abẹ abẹ, ati awọn ipa-ọna iṣan.Awọn ipa eto ara eniyan: iyipada ninu iṣẹ ṣiṣe mọto, isubu ninu titẹ ẹjẹ, miosis, didasilẹ pleural, idinku oṣuwọn pulse, oorun.Nigbati o ba gbona si jijẹ, o njade awọn eefin oloro pupọ ti NOx ati SOx